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The Valley of Death

The “Valley of Death” is a term I learned early on in the pharmaceutical industry as a developer of new therapeutic compounds. It refers to that period when moving from compound discovery to early-stage development, including pre-clinical toxicology and safety pharmacology studies, and few sources of money are available to keep programmes alive and people paid. At any point, a project can fall apart due to toxicity, costs, inactivity against targets, or several other unforeseen events. You may save a lot of mice in your preclinical efficacy animal models, but will you save humans with a safe drug? That is the key question.

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Randice Altschul
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News and Press Releases

BioIVT Acquires Optivia Biotechnology, Adding Transporter Assay Products and Services to its ADME-Tox Portfolio

BioIVT, a leading provider of research models and services for drug development, today announced that it has acquired Santa Clara, CA-based Optivia Biotechnology and its comprehensive portfolio of transporter assays, multi-transporter models, transporter systems biology, and molecular transport research solutions.
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Myoderm

Sourcing commercial drugs for clinical trials is a dynamic process. There are many factors to consider: single source or regional sourcing, strategy, price, supply availability, lead times, and documentation are just a few. In the past, there were fewer clinical trials that required commercial drug sourcing, so demand was not as high. Today, the demand for commercial drugs in clinical trials has greatly increased and, as a result, inventory is tighter, orders are monitored more closely by manufacturers, and lead times have increased. This report highlights the key differences in sourcing from the US and EU.
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Industry Events

PPMA SHOW 2018

25-27 September 2018, NEC, Birmingham, UK

The UK’s leading production line event is celebrating its 30th Anniversary. Taking place at the NEC, Birmingham from 25-27 September 2018, the exhibition showcases the latest processing and packaging machinery. Attended by thousands of manufacturers of food, pharmaceuticals and FMCG as well as contract packers and more.
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