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Pharmaceutical Manufacturing and Packing Sourcer

Pressing Matters

A crash course on making tablets and capsules is a daily request. Each and every week I field calls, test products, and assist customers with questions on how to make tablets and capsules, or how to make them better. The lab I use is equipped with all the machines and technology provided by the biggest names in business.

Choosing the Right Dosage Form

Deciding which dosage form to choose is guided by many factors. Marketing, competitive products, stability, shelf life, swallowability, and a host of other variables influence the decision. From a manufacturing point of view, it is generally known that it is easier to make a capsule than a tablet. The driving force in tablet and capsule development is the nature of the active ingredient(s). There are some key questions about the active ingredients that contribute to which dosage form (tablet or capsule) is required.

It’s important to understand that there are two categories of ingredients in a dosage form – the active(s) and excipient(s). The active ingredients are just that; they are the intended medications with a therapeutic effect. The excipient(s) are what I call the ‘other stuff’, things that assist the active ingredient. The key to putting a formula recipe together is to grasp that an excipient must have a function that aides the active ingredient when producing a tablet or capsule.

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Michael D Tousey, Technical Services Director and Founder of Techceuticals, which provides hands-on solid dose training, troubleshooting, and risk assessment worldwide. Michael has been active in the industry since 1973; as a machinist making tablet press tooling, and rebuilding tablet presses. He then worked as a maintenance mechanic for Shaklee Corporation dealing with tabletting, coating, granulating, and packaging, before moving into Sales and Service for Pennwalt Stokes-Merrill, Thomas Engineering, and O’Hara Technologies. In 1989 Michael founded Techceuticals, and is a contributing author in oral solid dosage tabletting industry publications.
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