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Nanoparticle Engineering for Patient-Centric Drug Formulation



As new drug candidates are discovered with the potential to revolutionise disease treatment, technological innovations that can help them to succeed in clinical trials and reach patients are of vital importance. In order for this to be achieved, a number of formulation challenges must be overcome. For example, the trend toward small-molecule drug candidates of ever-increasing complexity and molecular weight means that many struggle with poor solubility, inhibiting their absorption in the gastrointestinal (GI) tract, and effectively preventing them from achieving a therapeutic effect. Poor solubility and subsequent poor bioavailability, defined as the extent and rate at which a drug enters systemic circulation in an unchanged form, thereby reaching its target area, are leading causes of failure in smallmolecule drug development (1). It is down to formulation scientists to develop solutions to poor solubility that enable potentially life-changing drugs to reach their target area.

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Barry Derham, Senior Formulation Specialist at Nanoform, holds a DPhil in Biochemistry from Oxford University, UK. He previously worked in several positions in academia before moving into industry. Barry has over 14 years’ experience in formulation, working on biologics, vaccines, and small molecules. At Arecor, a liquid formulation company, he led internal research on transitioning new technologies to client projects. He was also involved in developing formulations for the next generation of vibrating mesh nebulisers and dry powder formulations produced by spray drying, at Vectura, an inhalation company. In his current role at Nanoform, his work focuses on the long-term stability of nanoformed particles.

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