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Pharmaceutical Manufacturing and Packing Sourcer
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Chiral substrates have attracted growing interest as important intermediates for catalysts, pharmaceuticals and agrochemicals and, in line with this trend, an increase in the sales volume for chiral technologies from .7 billion (2003) to billion in 2009 is forecasted by Frost & Sullivan (1). In principle, optically active compounds can be obtained by a number of different methods. In some cases, the chiral pool can provide simple and cost-effective access from natural sources.
However, the substrate spectrum is quite limited. Synthetic intermediates are often obtained as racemic mixtures. The resolution of racemates is an additional method for the synthesis of optically active molecules. On the downside, this process is often costly and time-consuming. More efficient procedures apply asymmetric catalytic systems for the synthesis of optically active intermediates. Catalysts used in these reactions can be subdivided in chemical and biological catalysts. A wide variety of chemical catalysts have been developed over the past decades. In 2001, Knowles, Noyori and Sharpless were honoured with the Nobel Prize for the development of analogous asymmetric catalysts. Nevertheless, a major drawback for these catalysts is the need of heavy metal cations as well as multi-step synthesis. |
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2012 BIO International Convention
18-21 June 2012, Boston, Massachusetts
Connect, partner and innovate at the 2012 BIO International Convention, June 18-21, Boston, Mass. Network with 15,000+ global biotech leaders in the BIO Business Forum, Exhibition and Programme.
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Delta Industrial Services to display at Pharmapack in France
Delta Industrial Services, a leader in web converting and packaging innovation, will be showcasing some of their recent developments in pharmaceutical manufacturing and pouching.
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