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Pharmaceutical Manufacturing and Packing Sourcer
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We have all experienced the terrible taste of some medicines, and most people just grin and bear it. But for some segments of society, such as the very young and the very old, the bad taste will result in the medication not being taken as often as it should, or even not at all. This presents the formulation scientist with a serious problem: how can this medicine be formulated to taste better? Making it taste better is known in the industry as 'taste masking', and there are several different ways to achieve this.
Taste masking can be divided into three different mechanistic approaches:
1. Hide the taste - do something that covers it up
2. Change the taste - do something to make it taste different
3. Reduce the taste - do something so that the drug does not dissolve in the mouth so that it cannot be tasted
Which method will work best depends on a number of variables, including: the type of formulation; how bad the API tastes; what type of taste the API has; and what type of release profile is needed once it has been swallowed. Often multiple methods are combined to give the desired result.
Hide the Taste
Cover the Taste with Pleasant Flavours
This is probably the oldest, best known and most common method. However, except for certain guidelines, the selection of the masking flavour is predominantly done by trial and error (1,2). For example, aspartame reduces the bitterness of acetaminophen, fenchone can mask the taste of eucalyptus oil, and a combination of sugars, apple flavours and amino acids reduce the bitterness of vitamins. Remington's (3) has an excellent summary of flavours and their uses, and includes discussions based on the main objectionable flavour categories of salty, bitter, sour and oily. The main limitations of this approach are that there may not be a suitable masking flavour and that people's perception of taste varies dramatically, so that what masks the taste for one person may not work for someone else. Therefore this is an intrinsically subjective approach. |
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Industry Events |
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3rd Annual Clinical Trial Management Systems (CTMS)
18-19 March 2010, Philadelphia, PA, US
Pharmaceutical and biotech companies are increasingly looking to clinical trial management systems (CTMS) to help streamline their clinical development operations. Building on a successful two-year history, this programme continues to serve as an excellent platform for industry discussion and collaboration among various CTMS stakeholders. This programme addresses the challenges of integrating CTMS systems both within the organisation across various other clinical systems as well as with external systems. Don’t miss this opportunity to hear in-depth industry case studies and learn from the challenges and successes of other companies.
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DB Schenker receives Accreditation as Qualified Envirotainer Provider in Europe and Asia High-quality solutions for integrated cold chain offered
DB Schenker has gained Accreditation as a Qualified Envirotainer Provider (QEP) at several stations in Europe and Asia by EnvirotainerAB, the Sweden-based provider of active temperature-controlled air cargo containers. The accreditation, which verifies that DB Schenker can manage temperature sensitive shipments that are shipped in Envirotainer containers in accordance with Good Distribution Practice, has been awarded for the European stations in Brussels, Basel, Frankfurt, Geneva, Mannheim, Stuttgart, Vienna and Zurich as well as the Singapore operation.
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