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Pharmaceutical Manufacturing and Packing Sourcer
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We have all experienced the terrible taste of some medicines, and most people just grin and bear it. But for some segments of society, such as the very young and the very old, the bad taste will result in the medication not being taken as often as it should, or even not at all. This presents the formulation scientist with a serious problem: how can this medicine be formulated to taste better? Making it taste better is known in the industry as 'taste masking', and there are several different ways to achieve this.
Taste masking can be divided into three different mechanistic approaches:
1. Hide the taste - do something that covers it up
2. Change the taste - do something to make it taste different
3. Reduce the taste - do something so that the drug does not dissolve in the mouth so that it cannot be tasted
Which method will work best depends on a number of variables, including: the type of formulation; how bad the API tastes; what type of taste the API has; and what type of release profile is needed once it has been swallowed. Often multiple methods are combined to give the desired result.
Hide the Taste
Cover the Taste with Pleasant Flavours
This is probably the oldest, best known and most common method. However, except for certain guidelines, the selection of the masking flavour is predominantly done by trial and error (1,2). For example, aspartame reduces the bitterness of acetaminophen, fenchone can mask the taste of eucalyptus oil, and a combination of sugars, apple flavours and amino acids reduce the bitterness of vitamins. Remington's (3) has an excellent summary of flavours and their uses, and includes discussions based on the main objectionable flavour categories of salty, bitter, sour and oily. The main limitations of this approach are that there may not be a suitable masking flavour and that people's perception of taste varies dramatically, so that what masks the taste for one person may not work for someone else. Therefore this is an intrinsically subjective approach. |
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Inaugural Peptides Europe
17-19 September 2009, Berlin, Germany
This year's event will be held in the exciting city of Berlin. The conference will be co-located with RNAi Europe, Advances in qPCR, and the Epigenetics World Congress. Registered delegates will also have access to these meetings ensuring a very cost-effective trip.
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Fundraisers Get on TRAC Thanks to Sponsorship Support
Robert Eddy and Paul Brown, from Penzance, will be taking part in the annual Mongol Rally in July, a charity car trek, which will see them clock up over 10,000 miles, driving a third of the way around the world, through some of the most inhospitable areas of the Northern Hemisphere in their 10 year old car. But thanks to Redruth-based regulatory affairs specialist TRAC, which works with some of the world’s leading pharmaceutical companies, the challenge has already started on a positive note after the company donated £500.
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