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| home > pmps > spring 2004 > achieve controlled release and increased bioavailability of pharmaceutical compounds through spray drying |
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Pharmaceutical Manufacturing and Packing Sourcer
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The recent interest in highly potent but poorly soluble pharmaceutical compounds has made controlled release and enhanced bioavailability of critical importance for many pharmaceutical dosage forms. This article describes spray drying techniques for manufacturing of products achieving controlled release and/or enhanced bioavailability. Four main categories of products are investigated, nano particles, microencapsulation, solid amorphous dispersions and dry emulsions.
Spray Drying
Spray drying is a very fast method of drying due to the large product surface area and high heat transfer coefficients available. The large surface area also allows for drying at a moderate to low temperature. These properties make spray drying feasible for heat sensitive materials. Rapid drying, and consequently fast stabilisation of feed material, makes spray drying ideally suited for encapsulation and producing dry emulsions or amorphous material. Particle engineering possibilities also include powder performance characteristics, such as aerodynamic particle size, geometric particle size, particle size distribution and powder flow properties.
Nano Particles
Spray drying of nano particles involves drying a suspension of nano particles in a suitable liquid, for example water. By spray drying, the primary particle size can be preserved and at the same time new desirable powder properties can be achieved. For example, powder with good flow properties and reduced tendency to produce air born dust or low aerodynamic particle size, combined with good powder flow properties. |
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