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Dynamic Modelling and Simulation for Nasal Drug Delivery

Nasal drug delivery is rapidly emerging as a route for drug administration. Computer aided engineering simulation tools, such as computational fluid dynamics (CFD), are extensively used across a wide range of industry sectors and this same technology is now being used for the simulation of nasal air flow passages and the deposition of drug particles. This article presents a study in which CFD simulation technology was applied. For the study, air flow velocities and distribution profiles of the drug particles were mapped as they travelled through the nasal cavity geometry chosen for analysis. The study also looked at the effects of key drug system formulation variables, such as particle size and densities, on drug deposition. The results show that simulations can be effectively used for the optimisation of nasal drug delivery systems, thereby minimising experimental work and clinical trials.

Nasal drug delivery systems are rapidly developing as a method of drug administration and are emerging as an alternative to oral and injection routes of delivery (1,2). Some of the key advantages of using the nasal administration route are the improved speed of the pharmacological action as a feature of improved accessibility to the vasculature, and the ability to achieve target-specific drug delivery.

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By Dr Jin Yan, Dr Atul Karanjkar and Martin Branagan, Healthcare Team at Fluent Europe Ltd

Dr Jin Yan is a Senior CFD Analyst at Fluent Europe Ltd working in Technical Services. He has a PhD in Thermodynamics from Durham University and has spent a total of five years at Fluent Europe working in both software and consultancy.

Dr Atul Karanjkar is Business Development Manager for Fluent Europe's Healthcare team. He has extensive experience within the health care industry in both Europe and North America. Dr Karanjkar has a PhD in Chemical Engineering and an MBA in Strategic Management.

Martin Branagan is Account Manager for Fluent Europe's Healthcare Team. He has over 12 years of health care industry experience through working at Smith & Nephew, where he was a Research Scientist, Project Manager and finally a Safety Consultant for the worldwide operations of the company, prior to joining Fluent.
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Dr Jin Yan
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Dr Atul Karanjkar
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Martin Branagan
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