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Pharmaceutical Manufacturing and Packing Sourcer
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Nasal drug delivery is rapidly emerging as a route for drug administration. Computer aided engineering simulation tools, such as computational fluid dynamics (CFD), are extensively used across a wide range of industry sectors and this same technology is now being used for the simulation of nasal air flow passages and the deposition of drug particles. This article presents a study in which CFD simulation technology was applied. For the study, air flow velocities and distribution profiles of the drug particles were mapped as they travelled through the nasal cavity geometry chosen for analysis. The study also looked at the effects of key drug system formulation variables, such as particle size and densities, on drug deposition. The results show that simulations can be effectively used for the optimisation of nasal drug delivery systems, thereby minimising experimental work and clinical trials.
Nasal drug delivery systems are rapidly developing as a method of drug administration and are emerging as an alternative to oral and injection routes of delivery (1,2). Some of the key advantages of using the nasal administration route are the improved speed of the pharmacological action as a feature of improved accessibility to the vasculature, and the ability to achieve target-specific drug delivery. |
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