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Pharmaceutical Manufacturing and Packing Sourcer
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With the trend towards pharmaceutical products of higher toxicity requiring greater standards of containment, the protection of mill systems against the consequences of a powder explosion are of ever-increasing importance.
The selection of explosion protection method is often made at a late stage in the mill system design when many other parameters have already been fixed. However, the method of protecting the system from an explosion can be highly interactive with other process requirements. In order to achieve an optimum overall design for the system, it is therefore necessary to have a good understanding of the relative merits of the various methods of explosion protection and to consider these at an early stage in the design process. The purpose of this article is to examine practical, cost-effective solutions to a variety of mill applications where the need is to provide total protection against the risk of a powder explosion whilst maintaining effective operational control over product emissions.
Why Containment?
The surge in demand for containment in the pharmaceutical industry, and indeed in other industries, is a direct reflection of the increased potency of modern drugs and the demands of ever-more stringent legislation. This has challenged the pharmaceutical companies and, in turn their equipment manufacturers, to meet the criteria. Here we consider the implications for manufacturers of size reduction equipment where impact, air-flow, temperature, high speed rotating components, bearings and seals are all design considerations in addition to the hazards of the product being processed. What are the Issues?
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By George Tunnicliffe, Pharmaceutical Business Manager, and Martin Thomson, Technical Sales Manager at Kemutec Group Ltd
George Tunnicliffe joined Kemutec in 1979 as Chief Design Engineer and in the early 1980s was seconded to assist in the start up of Kemutec Inc, the group's sister company in the USA. Following this, he was appointed Group Technical Manager, working on a variety of applications including cryogenic milling techniques, granulation processes and centrifugal sieves. In his current role as Business Manager for the Pharmaceutical and Packages Division he has responsibility for all activities within the division including sales, product development, test centre operations and systems engineering. George holds a BSc in Mechanical Engineering and sits on the technical sub-committee of the UK Solids Handling and Processing Association, which comprises around 100 UK organisations involved in the field of powder processing and handling.
Martin Thomson is a Graduate Engineer with an MSc in Bulk Powder Materials Handling from Glasgow Caledonian University, Scotland. He was presented with the Newcomer to Bulk Materials Handling Award by the Solids Handling Journal in 1992 for original work carried out on behalf of BP Chemicals. Martin joined Kemutec Group in 1993 and has spent the last 10 years working closely with pharmaceutical companies around the world, gaining hands on experience in solving their powder processing requirements. His early positions as Commissioning Engineer, Site Manager and his current role as Technical Sales Manager have allowed him the opportunity to witness first hand the typical problems associated with the milling of pharmaceutical powders.
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Industry Events |
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Inaugural Conference on Pre-Filled Syringes
21-22 January 2009, Crowne Plaza Hotel - St James, London, UK
SMi present their Inaugural Conference on Pre-Filled Syringes 21st and 22nd January 2009 at the Crowne Plaza Hotel - St James, London, UK
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News and Press Releases |
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Azopharma Product Development Group, Inc
HOLLYWOOD, Fla. – Azopharma Product Development Group, Inc. (“Azopharma”) announced today the addition of innovative state-of-the-art equipment at its formulation and manufacturing division, ApiCross Drug Delivery Technologies in Hollywood, Florida. The most recent acquisition is the MG Futura Capsule Filler which delivers the latest in capsule filling technology. The company has also added a Bausch & Strobel Aseptic Filling Isolator, equipment that is ground-breaking in the powder filling process. These additions support our previously implemented XcelodoseTM powder micro-dosing system. With these technologies, Azopharma is able to provide its clients with all forms of the capsule filling process. The new equipment is part of Azopharma’s recent manufacturing expansion which includes 17 new manufacturing suites for GMP, cytotoxic and aseptic products...
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