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| home > pmps > winter 2003 > taking nasal drug delivery seriously: examples of pain-free and user-friendly alternative |
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 PUBLICATIONS |
Pharmaceutical Manufacturing and Packing Sourcer
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Nasal Drug Delivery
Nasal sprays and drops have been used extensively for decades to prevent and treat ailments such as nasal congestion and allergic rhinitis. More recently the nasal route has been recognised as a convenient, reliable and non-invasive alternative to the parenteral route for the systemic administration of several compounds. Using this delivery route, nasal mucosa acts as a portal of entry for drugs into the bloodstream and potentially has a similar pharmaco-kinetic profile as drugs delivered intravenously. In particular, research has been exploring the direct transport of drugs from the nasal cavity to the central nervous system (CNS).
Drug development in the 21st century will not only rely on innovative new compounds and sophisticated formulations, but also on the efficiency, safety and comfort of the dispensing systems. The ideal 'nasal spray drug delivery device' should have optimum performance, (accurate and reproducible dose, narrow spray droplet size distribution; and support patient compliance, thus contributing to the reduction in global health expenditure. In addition, patients are now behaving more like consumers, and key issues such as device convenience, ease-of-use, attractiveness of the design and style, will reinforce brand recognition and loyalty, which will ultimately contribute to product success.
Nasal devices have progressively evolved from pipettes and droppers through to spraying devices such as squeeze bottles (which do not control the dose of drug delivered or the quality of the spray), towards metering spray pumps and valves and unit-dose nasal spray devices.
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