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| home > pmps > spring 2003 > probiotics: manufacturing and packaging considerations and recent developments in oral delivery |
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Pharmaceutical Manufacturing and Packing Sourcer
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Successful dietary supplementation of live probiotic bacteria must function within a set of parameters similar to those faced by orally administered pharmaceuticals. The stability of a drug compound within a dosage form and the drug's oral bioavailability are critical parameters to consider when applying a delivery system to any pharmaceutical product. An analogous set of parameters - stability within a dosage form and viability after release - also applies to the administration of probiotic bacteria.
These parameters are dependent on both the design of the dosage form itself and the in vivo environment of the GI tract. The performance and efficacy of a probiotic tablet or capsule is affected by processing parameters, packaging type and materials, as well as the individual excipients selected within the formulation. Development considerations must encompass production, including raw materials and method of manufacture, packaging of the finished tablet or capsule and the in vivo stability of the formulation or delivery system. Passage through the GI tract will subject the dosage form to large fluctuations in pH and erosional forces that will impact performance and survival of the probiotic contents.
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By Michael Hite, Lead Research Associate, Stephen Turner, Director of Product Development, and Cathy Federici, Research Associate, members of the Research and Product Development Group at SCOLR® Inc
Michael Hite, Lead Research Associate, Stephen Turner, Director of Product Development and Cathy Federici, Research Associate are all members of the Research and Product Development group at SCOLR® Inc, a drug delivery company specialising in the development and application of novel oral drug delivery systems. Michael is a graduate of Amherst College, Stephen is a graduate of Western Washington University and Cathy a graduate of Swarthmore College. They joined SCOLR® in 2000, 1999 and 2001 respectively.
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News and Press Releases |
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Azopharma Product Development Group, Inc
HOLLYWOOD, Fla. – Azopharma Product Development Group, Inc. (“Azopharma”) announced today the addition of innovative state-of-the-art equipment at its formulation and manufacturing division, ApiCross Drug Delivery Technologies in Hollywood, Florida. The most recent acquisition is the MG Futura Capsule Filler which delivers the latest in capsule filling technology. The company has also added a Bausch & Strobel Aseptic Filling Isolator, equipment that is ground-breaking in the powder filling process. These additions support our previously implemented XcelodoseTM powder micro-dosing system. With these technologies, Azopharma is able to provide its clients with all forms of the capsule filling process. The new equipment is part of Azopharma’s recent manufacturing expansion which includes 17 new manufacturing suites for GMP, cytotoxic and aseptic products...
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