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Pharmaceutical Manufacturing and Packing Sourcer

Probiotics: Manufacturing and Packaging Considerations and Recent Developments in Oral Delivery

Successful dietary supplementation of live probiotic bacteria must function within a set of parameters similar to those faced by orally administered pharmaceuticals. The stability of a drug compound within a dosage form and the drug's oral bioavailability are critical parameters to consider when applying a delivery system to any pharmaceutical product. An analogous set of parameters - stability within a dosage form and viability after release - also applies to the administration of probiotic bacteria.

These parameters are dependent on both the design of the dosage form itself and the in vivo environment of the GI tract. The performance and efficacy of a probiotic tablet or capsule is affected by processing parameters, packaging type and materials, as well as the individual excipients selected within the formulation. Development considerations must encompass production, including raw materials and method of manufacture, packaging of the finished tablet or capsule and the in vivo stability of the formulation or delivery system. Passage through the GI tract will subject the dosage form to large fluctuations in pH and erosional forces that will impact performance and survival of the probiotic contents.


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By Michael Hite, Lead Research Associate, Stephen Turner, Director of Product Development, and Cathy Federici, Research Associate, members of the Research and Product Development Group at SCOLR® Inc

Michael Hite, Lead Research Associate, Stephen Turner, Director of Product Development and Cathy Federici, Research Associate are all members of the Research and Product Development group at SCOLR® Inc, a drug delivery company specialising in the development and application of novel oral drug delivery systems. Michael is a graduate of Amherst College, Stephen is a graduate of Western Washington University and Cathy a graduate of Swarthmore College. They joined SCOLR® in 2000, 1999 and 2001 respectively.
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Stephen Turner
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Michael Hite
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Cathy Federici
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