|
|
|
| home > pmps > summer 2003 > preservative-free - the new standard for nasal drug delivery |
|
|
 PUBLICATIONS |
Pharmaceutical Manufacturing and Packing Sourcer
|
The German market for nasal preparations sold by pharmacies is about ˆ250 million whereas the number of unpreserved formulations has increased significantly during the last few years. In the past, nasal drug applications in multi-dose containers had to contain preservatives in order to maintain the quality of the drug as well as to protect patients from infections. More recently several pump-device manufacturers (for example Pfeiffer, Sofab, Ursatec, Valois) have developed intelligent application systems that function without preservatives. Because physicians as well as scientists are concerned about the significant unwanted side-effects of preservatives, many drug manufacturers have changed to preservative-free applications. It is foreseeable that preservative-free systems will play an increasingly important role in the future of drug delivery. So what are the advantages provided by these systems and the reasons for the success of the preservative-free nasal drug application?
First of all, concerns about preservatives and their side-effects arouse a feeling of insecurity in the pharmaceutical industry as well as among customers. Their effectiveness is based on biocidal and killing properties against most germs. Unfortunately, at the same time preservatives often cause unwanted side-effects concerning the clearance and defence mechanisms of the nose, such as inhibition of cilia motility (1-3).
|
Read full article from PDF >>
|
|
 |
|
| Rate this article |
You must be a member of the site to make a vote. |
|
Average rating: |
0 |
| | | | | |
|
|
 |
Industry Events |
 |
3rd African Regulatory Conference (ARC)
3-4 May 2012, Accra, Ghana
The African Regulatory Conference offers the opportunity for key stakeholders active on the continent, including representatives from Ministry of Health, local and multinational pharmaceutical companies, to meet to exchange views, discuss topics of interest and identify focus areas for ongoing efforts to increase patient access to new and improved medicines.
More info >> |
|
 |
News and Press Releases |
 |
Firstan Ltd are first to achieve the new Pharmaceutical PS9000:2011 quality standard
Firstan Ltd, the UK’s leading independently owned Pharmaceutical and Food Carton producer have become the first UK Packaging company to achieve the new Pharmaceutical PS9000:2011 quality standard for its Healthcare Division. This standard was published in September 2011 in consultation with industry suppliers, pharmaceutical companies and other stakeholder organisations. Firstan have held the Pharmaceutical accreditation for almost 20 years.
More info >> |
|
|
