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home > pmps > summer 2003 > preservative-free - the new standard for nasal drug delivery
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Pharmaceutical Manufacturing and Packing Sourcer

Preservative-Free - The New Standard for Nasal Drug Delivery

The German market for nasal preparations sold by pharmacies is about 250 million whereas the number of unpreserved formulations has increased significantly during the last few years. In the past, nasal drug applications in multi-dose containers had to contain preservatives in order to maintain the quality of the drug as well as to protect patients from infections. More recently several pump-device manufacturers (for example Pfeiffer, Sofab, Ursatec, Valois) have developed intelligent application systems that function without preservatives. Because physicians as well as scientists are concerned about the significant unwanted side-effects of preservatives, many drug manufacturers have changed to preservative-free applications. It is foreseeable that preservative-free systems will play an increasingly important role in the future of drug delivery. So what are the advantages provided by these systems and the reasons for the success of the preservative-free nasal drug application?

First of all, concerns about preservatives and their side-effects arouse a feeling of insecurity in the pharmaceutical industry as well as among customers. Their effectiveness is based on biocidal and killing properties against most germs. Unfortunately, at the same time preservatives often cause unwanted side-effects concerning the clearance and defence mechanisms of the nose, such as inhibition of cilia motility (1-3).


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By Dr Simone Bagel, Partner and Managing Director of Antiinfectives Intelligence GmbH

Dr Simone Bagel gained a PhD in Biology and has worked for several years in the fields of antibiotic research and analysis and quality control of medications in the Department of Pharmaceutical Microbiology, University of Bonn.

As Partner and Managing Director of Antiinfectives Intelligence GmbH, she is Head of Research and Development. One field of work focuses on preservative-free nasalia and the development of test methods as well as ongoing quality controls.

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Dr Simone Bagel
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