samedan logo
 
 
 
spacer
home > pmps > summer 2003 > preservative-free - the new standard for nasal drug delivery
PUBLICATIONS
Pharmaceutical Manufacturing and Packing Sourcer

Preservative-Free - The New Standard for Nasal Drug Delivery

The German market for nasal preparations sold by pharmacies is about ˆ250 million whereas the number of unpreserved formulations has increased significantly during the last few years. In the past, nasal drug applications in multi-dose containers had to contain preservatives in order to maintain the quality of the drug as well as to protect patients from infections. More recently several pump-device manufacturers (for example Pfeiffer, Sofab, Ursatec, Valois) have developed intelligent application systems that function without preservatives. Because physicians as well as scientists are concerned about the significant unwanted side-effects of preservatives, many drug manufacturers have changed to preservative-free applications. It is foreseeable that preservative-free systems will play an increasingly important role in the future of drug delivery. So what are the advantages provided by these systems and the reasons for the success of the preservative-free nasal drug application?

First of all, concerns about preservatives and their side-effects arouse a feeling of insecurity in the pharmaceutical industry as well as among customers. Their effectiveness is based on biocidal and killing properties against most germs. Unfortunately, at the same time preservatives often cause unwanted side-effects concerning the clearance and defence mechanisms of the nose, such as inhibition of cilia motility (1-3).


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
By Dr Simone Bagel, Partner and Managing Director of Antiinfectives Intelligence GmbH

Dr Simone Bagel gained a PhD in Biology and has worked for several years in the fields of antibiotic research and analysis and quality control of medications in the Department of Pharmaceutical Microbiology, University of Bonn.

As Partner and Managing Director of Antiinfectives Intelligence GmbH, she is Head of Research and Development. One field of work focuses on preservative-free nasalia and the development of test methods as well as ongoing quality controls.

spacer
Dr Simone Bagel
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Cognizant Shared Investigator Platform for Life Sciences Reaches Major Milestone in Accelerating Drug Discovery

Cognizant (Nasdaq: CTSH) announced that its Shared Investigator Platform (SIP), a life sciences Software as a Service (SaaS) solution, has reached a new milestone of over 100,000 users in 84 countries. The platform has become increasingly critical to progressing clinical trials as prevailing social distancing norms have significantly curtailed in-person collaboration.
More info >>

White Papers

Transforming Temperature Data Management Practices to Reduce Labor Costs and Improve Visibility and Control

Berlinger & Co AG

There are a number of temperature monitoring database options available to the biopharma supply chain professional and choosing the right one can significantly improve workflow which will reduce administrative time. This article will provide insight into practices for improving common processes through enhanced database functionality in the areas of managing data loggers by expiry date, storing and retrieving calibration certificates and acknowledging/documenting common temperature excursion events. Additionally, it describes the unique features and benefits of the Berlinger Smartview® data management system. Smartview® is a “Software as a Service” (SaaS) platform designed to efficiently and accurately manage both workflow and data in a regulatory compliant manner (21 CRF Part 11 & Annex 11). This comprehensive temperature data management system ensures reliability, accuracy, security, accessibility, and visibility to supply chain professionals, enhancing Good Distribution Practices (GDP) of temperature sensitive shipments.
More info >>

 
Industry Events

World Vaccine Congress Washington

27-29 September 2020, Walter E Washington Convention Center, Washington, US

The World Vaccine Congress is an award-winning series of conferences and exhibitions that have grown to become the largest and most established vaccine meeting of its kind across the globe. Our credibility is show through the prestigious scientific advisory board that spend months of hard work creating a new and topical agenda, year on year.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement