|
 |
| home > pmps > summer 2003 > preservative-free - the new standard for nasal drug delivery |
|
|
 PUBLICATIONS |
Pharmaceutical Manufacturing and Packing Sourcer
|
The German market for nasal preparations sold by pharmacies is about ˆ250 million whereas the number of unpreserved formulations has increased significantly during the last few years. In the past, nasal drug applications in multi-dose containers had to contain preservatives in order to maintain the quality of the drug as well as to protect patients from infections. More recently several pump-device manufacturers (for example Pfeiffer, Sofab, Ursatec, Valois) have developed intelligent application systems that function without preservatives. Because physicians as well as scientists are concerned about the significant unwanted side-effects of preservatives, many drug manufacturers have changed to preservative-free applications. It is foreseeable that preservative-free systems will play an increasingly important role in the future of drug delivery. So what are the advantages provided by these systems and the reasons for the success of the preservative-free nasal drug application?
First of all, concerns about preservatives and their side-effects arouse a feeling of insecurity in the pharmaceutical industry as well as among customers. Their effectiveness is based on biocidal and killing properties against most germs. Unfortunately, at the same time preservatives often cause unwanted side-effects concerning the clearance and defence mechanisms of the nose, such as inhibition of cilia motility (1-3).
|
Read full article >>
|
|
 |
|
| Rate this article |
You must be a member of the site to make a vote. |
|
Average rating: |
0 |
| | | | | |
|
|
 |
Industry Events |
 |
Inaugural Conference on Pre-Filled Syringes
21-22 January 2009, Crowne Plaza Hotel - St James, London, UK
SMi present their Inaugural Conference on Pre-Filled Syringes 21st and 22nd January 2009 at the Crowne Plaza Hotel - St James, London, UK
More info >> |
|
 |
News and Press Releases |
 |
Stora Enso with DDSi is Winner of HCPC-Europe Packaging Award 2008
11th November 2008
More info >> |
|
|
