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Lipid Emulsions as Drug Delivery Systems

Introduction

Recent advances in combinatorial chemistry techniques employed in the pharmaceutical industry have dramatically increased the number of new compounds for evaluation as drug candidates. Approximately half these new chemical entities contain hydrophobic substituents that result in the compounds exhibiting poor aqueous solubility. This lipophilic attribute offers the capability in tailoring the formulation of a new chemical entity into a lipid emulsion drug delivery system to accommodate the specific requirements of the disease with respect to stability, toxicity and efficacy in parenteral administration.

Types of Emulsions for Parenteral Drug Delivery

An emulsion is a dispersion of two or more immiscible liquids stabilised by a surfactant or emulsifier coating the droplets and preventing coalescence by reducing interfacial tension or creating a physical repulsion between the droplets (1). Two common types of emulsions are found in parenteral drug delivery systems. Water in oil emulsions (W/O) are used in sustained release of steroids and vaccines by intramuscular injection. Oil in water (O/W) or lipid emulsions can be administered by a variety of parenteral routes (for example subcutaneous, intramuscular, intra-arterial), but are predominantly injected intravenously in parenteral nutrition applications.


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By Jack Stevens, Associate Foundation Scientist, Pam Mims, Director of Product Support and Services and Neil Coles, Marketing and Business Development Liaison at Fresenius Kabi Clayton Inc

Jack Stevens is the Associate Formulation Scientist at Fresenius Kabi Clayton NC, a contract pharmaceutical manufacturing and development company of sterile parenteral products such as injectable solutions, liposomes or emulsions. Jack received a BS in Chemistry from Kutztown University and a MS in Chemistry from Villanova University and has been with the company for four years.


Pamela Mims is the Director of Product Support and Services and has been with Fresenius Kabi for over fifteen years. Her group consists of research scientists performing formulation development, process scale-up, analytical method development, validation and stability studies. Pam received her BS in Animal Science and her MS in Nutrition from North Carolina State University.


Neil Coles serves as the Marketing and Business Development Liaison at Fresenius Kabi and has been with the company for nine years. He is responsible for maintaining client relationships in contract research and manufacturing alliances, and is the US representative for business development for Fresenius Product Partnering. Neil is a graduate of the State University of New York at Buffalo School of Pharmacy, with a BS in Medicinal Chemistry.


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Jack Stevens
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Pamela Mims
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Neil Coles
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