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High Purity Gas Generation for use in Drug Delivery Preparation and Pharmaceutical Manufacturing

The types and uses of process gases in drug delivery preparation and pharmaceutical manufacturing are many and varied. The virtually inert attributes of nitrogen make it suitable for blanketing and purging, while hydrogen, zero-air, TOC-free air, along with nitrogen all find uses within manufacturing process quality laboratories. Today it is possible to generate all of these gases on-site using standalone gas generators.

Applications of High Purity Gases in Drug Delivery and Manufacturing

The diversity of applications for high purity gases within pharmaceutical manufacturing is extremely wide-ranging. It is worthwhile mentioning some of the most common. Blanketing with nitrogen is an important process used to protect volatile substances, which react with oxygen or water vapour. By surrounding the substance with a protective layer of dry, inert gas, the stability of the substance can be maintained without any degradation. Controlled flow may be used to preserve the density of the nitrogen blanket. Purging involves the flushing of a vessel with nitrogen to dispel oxygen and moisture, usually at process start-up or shutdown.


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By Dr Graham Kerr, Head of R&D, Products of Technology Ltd, and Dr Vic Young, Process Development Manager, Encap Drug Delivery

Dr Graham Kerr joined Products of Technology in 2002 as Head of Research & Development. He has many years of industrial experience in design, manufacturing and product development, having held senior engineering positions at Motorola Manufacturing Systems and Babcock Technology Centre. He holds a PhD in Physics from the University of Glasgow where he spent several years as a Research Associate within the Physics & Astronomy department.


Dr Vic Young graduated from Heriot Watt University with a PhD in Chemistry and started his professional career as an analyst with the Medicines Testing Laboratory in Edinburgh. He joined Encap at its formation in 1989 as QC Manager where he set up the QC lab and then, after several years, changed to become Production Manager for a further six years until taking over his present role of Process Development Manager.


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Dr Graham Kerr
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Dr Vic Young
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