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Pharmaceutical Manufacturing and Packing Sourcer
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In the days of muzzle loaders the most important thing was to keep your gunpowder dry. In 1649 Oliver Cromwell wanted his troops to stay prepared for action and is often quoted as saying, "Put your trust in God; but be sure to keep your powder dry". Over 350 years later, and with reference to dry powder inhalers, the sentiment is the same. It may be a great active and device, but only if you keep your powder dry.
This article discusses the importance of moisture in determining the performance of a dry powder inhaler (DPI) system; the concept of a moisture budget for a DPI; the sources of moisture; how these can be understood; and the protection of a DPI from the harmful effects of moisture. It outlines an approach to investigation of product and packaging integrity and how assessment of container integrity could be used to quickly determine potential product stability. This would conventionally take many months in an environmental chamber.
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