spacer
home > pmps > winter 2002 > modified-release oral solid dosage forms - part i: coating and matrix formation
PUBLICATIONS
Pharmaceutical Manufacturing and Packing Sourcer

Modified-Release Oral Solid Dosage Forms - Part I: Coating and Matrix Formation

This article provides a comprehensive review of the basics of matrix and coating systems on which new drug delivery companies have based their products. It focuses on the investigation of the underlying technical principles of oral solid dosage forms (tablets and particles) by classifying them as matrix or coating systems. The materials chemistry and processing (formulation and formation methods) of matrix or coating oral solid dosage forms have been investigated. Processing of commercial matrix or coating systems is different.

The conventional processing described provides the basics for what is now all-in-one granulation using fluid beds (top-spray for matrices and bottom or tangential-spray for coatings). Each system's specific parameters (polymer hydration and gel formation for matrices, insolubility for coatings) and common parameters (particle size, shape of all particles, drug per cent, polymer blend solubility, flexibility and compressibility) are discussed. The current trends resulted from these basic technical formation principles.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
By Emmanuel Dimotakis PhD and Robert A Nash PhD, Department of Chemical
and Pharmaceutical Engineering at the New Jersey Institute of Technology

Dr Emmanuel Dimotakis joined Sun Chemical as an Associate Scientist in 1998 and is currently a Scientist II. His expertise is in product development with emphasis on nanostructure-property relationships and formulation/rheology of polymers for coatings/colorants, nanomaterials and lithography. He has introduced products into the market, published 15 articles, 3 US/WO Patents (others are pending) and 12 government reports to NASA/DOD.

He was formerly with E. Merck and before that with MER Corporation. Dr Dimotakis received his PhD in Chemistry at Michigan State University in 1990 and undertook Postdoctoral work in Materials Science and Engineering at the University of Illinois at Urbana-Champaign.

Dr Robert A Nash is Adjunct Professor of Pharmaceutical Engineering at Stevens Institute of Technology in Hoboken, USA. Before that he taught at NJIT and St John's University.

Dr Nash spent 24 years in the US pharmaceutical industry with Merck, Lederle and the Purdue Frederick Co. in roles varying from Researcher to Manager of Pharmaceutical R&D. Dr Nash is Co-Editor of Pharmaceutical Process Validation published by Marcel Dekker & Co, New York. He is also a Consultant to the US FDA on validation and GMP matters.


spacer
Dr Emmanuel Dimotakis
spacer
spacer
spacer
Dr Robert A Nash
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Clinical Trial Supply West Coast Conference 2019

Philadelphia, USA – April 24, 2019. This year’s Clinical Trial Supply West Coast Conference will see leading biopharmaceutical outsourcing services provider PCI Pharma Services (PCI) showcasing its specialist clinical trials expertise in relation to scheduled drugs.
More info >>

White Papers

Detecting Integrity Breaches in a range of Pharmaceutical Blister Package Types using Sepha VisionScan

Sepha Limited

Demonstrating the integrity of pharmaceutical blister packs is critically important, as any defects can affect the shelf life and efficacy of the contents. Compared to bulk packaging, blister packs offer improved product integrity, tamper evidence and reduce the likelihood of misuse. Packs can be composed of either a thermoformed polymer or cold formed aluminium tray, with a number of individual pockets to hold the product. After the tablets or capsules are placed in the pockets, the packs are heat sealed with a paper or foil laminate sheet. These various stages can be completed separately or integrated into a single form, fill and seal process. There is a risk of microbial containment or degradation of the contents if any defects are present in the packaging. Such defects can take the form of rips or pinholes in the tray, or lid materials, faulty seals and channel leaks between pockets.
More info >>

 
Industry Events

The Universe of Pre-filled Syringes and Injection Devices

22-23 October 2019, The Swedish Exhibition & Congress Centre Gothia Towers Hotel

PDA’s Universe of Pre-filled Syringes and Injection Devices has become the must-attend meeting for everyone working in the field, and is now the world’s largest conference on this subject
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement