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| home > pmps > winter 2002 > modified-release oral solid dosage forms - part i: coating and matrix formation |
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Pharmaceutical Manufacturing and Packing Sourcer
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This article provides a comprehensive review of the basics of matrix and coating systems on which new drug delivery companies have based their products. It focuses on the investigation of the underlying technical principles of oral solid dosage forms (tablets and particles) by classifying them as matrix or coating systems. The materials chemistry and processing (formulation and formation methods) of matrix or coating oral solid dosage forms have been investigated. Processing of commercial matrix or coating systems is different.
The conventional processing described provides the basics for what is now all-in-one granulation using fluid beds (top-spray for matrices and bottom or tangential-spray for coatings). Each system's specific parameters (polymer hydration and gel formation for matrices, insolubility for coatings) and common parameters (particle size, shape of all particles, drug per cent, polymer blend solubility, flexibility and compressibility) are discussed. The current trends resulted from these basic technical formation principles.
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Small Scale Biomanufacturing – clinical trials, cell & gene therapies
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