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Needle-Free Injectors - Advantages, Current Technologies and Future Innovations

Advantages of Needle-Free Delivery Technology

As many as 10 billion injections of medications and vaccines are given to patients every year, administered in the vast majority of cases with a needle and syringe. While the simplicity and efficacy of this method of drug delivery is indisputable, it suffers from several drawbacks with respect to safety and acceptability. Prominent among these is the potential for needle-stick injuries, in which a health care provider is inadvertently pricked with a needle previously used for administering an injection. These injuries represent opportunities for the transmission of infectious disease, and therefore require extensive post-event surveillance and, in many cases, prophylactic treatment of the victim with expensive and toxic drugs. With estimates of the number of such injuries occurring annually in the US ranging as high as 800,000, needle-sticks represent both a serious safety problem and a considerable financial burden for the health care industry (1,2). An additional disadvantage of hypodermic needles is the significant expense required for their safe disposal. Finally, many patients are needle-averse, which can lead to significant problems with compliance (3).

Needle-free injection of medications and vaccines represents an alternative method of parenteral drug delivery that is as effective as needle and syringe but free of many of the aforementioned problems. Needle-free injection devices generate a fine stream of medication at high pressure, which penetrates the skin to deposit medication at the desired depth. The absence of hypodermic needles from the injection process removes the potential for needle-stick injuries and simplifies disposal. The rapidity of needle-free injections (typically a second or less) further enhances patient compliance and acceptance.


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By Lawrence Baizer of Bioject Incorporated, John Hayes of Antares Pharma Incorporated, Christine Lacey of PowderJect, Plc, Linda D'Antonio of DCI East Syracuse and Mike Mathews of Felton International Dr Lawrence Baizer obtained a degree in Biology from Cornell University, USA and a PhD in Pharmacology from the University of Colorado Health Sciences Center. He received postdoctoral training in molecular neurobiology at Massachusetts General Hospital/Harvard Medical School and pursued further research in this field as an Independent Investigator. He was an Assistant Professor of Pharmacology at the Oregon Health Sciences University from 1988 to 1990 and a Scientist at the RS Dow Neurological Sciences Institute from 1990 to 2000.
Lawrence joined the clinical department of Bioject in 2000, where he co-ordinates research collaborations and assists in exploring new applications for Bioject's needle-free injection technology.

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