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| home > pmps > summer 2002 > unit-dose nasal sprays - systemic delivery through the nose |
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Pharmaceutical Manufacturing and Packing Sourcer
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In recent years, the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of several compounds. In such cases, the nasal mucosa is used as a portal of entry for drugs into the bloodstream. Conventional drug delivery devices used for the nasal route include metering spray pumps, pressurised metered dose inhalers, squeeze bottles and, to a lesser extent, nasal drops. They are all used in conjunction with liquid formulations (solutions or suspensions). Another unusual but promising approach is to dispense dry powder formulations to/through the nasal mucosa.
Unit-Dose Nasal Sprays
These designate small disposable devices that deliver a limited number of sprays, for example, one or two shots (one per nostril). Another attribute is that they are 'ready to use' - there is no need to shake and/or prime the device prior to use. In addition, they can be used in any position. Examples of commercial pharmaceutical products that use unit-dose nasal spray devices:
Calcitonin, Aventis
Calcitonin, ICN
Inflexal Flu Vaccine, Berna Biotech
Sumatriptan, GlaxoSmithKline
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