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Advances in Tabletting

There are three main areas in which advances in tabletting will be discussed in this article:
Measuring and understanding the behaviour of materials during compression
Excipients
The impact of regulatory authorities

The Beginnings of Tabletting

Arabian manuscripts from the latter half of the 10th Century have been discovered which describe 'tablet moulds' formed by engraving hollow impressions in two facing pieces of ebony, wood, ivory or stone.
In the UK, in 1843, William Brockendon was granted patent number 9977 "For the shaping of pills, lozenges and black lead by pressure in a die". Prior to this, the usual practice was to form pills from wetted powders which were rolled out rather like pastry, cut to size and then 'balled' by rolling.


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By Dr John Fell of the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester, and Consultant to Manesty's Process Development Group. Dr John Fell is a Senior Lecturer within the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester, UK. John has recently been appointed as a Consultant to Manesty's process development group. He has a wealth of experience in pharmaceutical technology across the product range.
At the University of Manchester, John is involved with both the mechanics of solid dosage production and the efficacy of clinical performance. He has published over 100 scientific papers and speaks on the subject of solid dosage forms at numerous conferences. He is currently organiser of a course on tablet and capsule formulation which is run by the European Continuing Education College.

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Dr John Fell
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