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Pharmaceutical Manufacturing and Packing Sourcer

When Bioavailability or Stability is a Problem

Soft gelatine capsules often improve the performance of drugs insoluble in water or gastric juices. Certain drugs such as neutral compounds or organic acids are insoluble in water and gastrointestinal fluids and, if presented as tablets or hard shell capsules, the absorption rate is low and bioavailability correspondingly poor. In these cases, several methods can be employed to minimise the problem (see Figure 1). For example, neutral compounds may be formulated as a fine suspension, using powders or dispersible tablets, although such presentations are often not the ideal form for marketing purposes.

Alternatively, combination with surfactants or polymers can produce a solid solution that will dissolve rapidly but which may be chemically unstable or waxy, making it difficult to process.


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By Peter Sharper, Export Director of Pharmagel UK
Peter Sharper, Export Director of Pharmagel UK, is a Biologist. Since 1974 he has worked in a marketing and technical capacity for a number of companies in the industry, including Upjohn, Eli Lilly, R.P. Scherer and Pharmagel.
He has been responsible for the creation of more than 25 softgel capsule plants worldwide.

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Peter Sharper
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