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Pharmaceutical Manufacturing and Packing Sourcer

Dosage Dilemmas

AN IMPRECISE SCIENCE

Ensuring the correct dosage of milligram amounts of powders into capsules has traditionally been a difficult and imprecise science for pharmaceutical companies, particularly as the material is significantly lighter than the weight of the capsule shell.

Administration of minute amounts of drugs into hard gelatine capsules, for instance, can be problematic due to the forces of agglomeration and cohesion, resulting in a poor flow which could cause the weight of the dose to fluctuate between 15 and 20 per cent – an unacceptable condition when handling pharmaceutical products.

ADVANCING AUTOMATION

In the search for a process which can automatically provide accurate and precise weight measurements for dispensing microdoses of powder into capsules, significant advances have been made. Until now, this process has mostly been carried out on standard automatic machines that have been adapted with dosing mechanisms to handle such small quantities of powder, but because capsules were not weighed prior to filling, it was impossible to make reliable estimations as to the weight of the capsule’s content.


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Robin Davies is Managing Director of Isopak Ltd, a leading UK supplier of equipment to the pharmaceutical, healthcare industries and also exclusive distributor in the UK of Italy-based MG2’s quality range of machines. Before starting Isopak, Robin ran Stamford Packaging, before becoming the Sales Manager for CAM, a major Italian packaging machine manufacturer. He has also been Chief Engineer for a company called Peter Holland, a distributor for a range of manufacturers of packaging.
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