spacer
home > news > detailed info
INDUSTRY NEWS AND PRESS RELEASES

BioMed X Institute and Healthcare Business of Merck KGaA, Darmstadt, Germany, Start New Research Project in Oncology

BioMed X



HEIDELBERG, Germany, August 1, 2022 / B3C newswire /
-- BioMed X, a German independent research institute, announces the start of its new research project ‘Extrachromosomal DNA in Cancer’ (EDC) in collaboration with Healthcare Business of Merck KGaA, Darmstadt, Germany. The main objective of this research group is to develop an atlas of extrachromosomal DNA (ecDNA) in human cancer tissues and thereby trace back the mechanisms of ecDNA formation and function.

Like the name suggests, extrachromosomal DNA refers to DNA sequences that are not located on chromosomes. Moreover, cancer-associated extrachromosomal DNA usually contains oncogenes and regulatory regions that can provide a selective growth advantage, such as drug resistance, to the cancer cells who possess it, while also rapidly leading to increased intratumoral genetic heterogeneity.

Dr. Alexandros Drainas, group leader of team EDC, explains why this is relevant for cancer treatment: “Oncogene amplification plays a central role in tumorigenesis, and ecDNA is a frequent and effective mechanism for gene amplification in cancer cells. We need to understand the precise biology of these DNA elements in order to design more potent anticancer treatments, especially for aggressive forms of cancer that rapidly become resistant to therapies.” To lead this project, Dr. Drainas has returned to Heidelberg, the place where he obtained his PhD at the European Molecular Biology Laboratory (EMBL), before moving to Stanford University, for his postdoctoral appointment studying drug resistance and tumor heterogeneity.

This is the seventh collaboration on an oncology topic between the BioMed X Institute and the Healthcare Business of Merck KGaA, Darmstadt, Germany, and the third currently active project developing innovative anticancer therapies. The other two Darmstadt-partnered cancer research teams at the BioMed X Institute are studying RNA Splicing in Cancer and Synthetic Lethality in DNA Repair. Rather than studying a particular cancer type, all three projects aim to understand the essentials of how the biology is altered in the context of cancer.

“With these three current projects, we are at the forefront of deep cancer biology, and complying with our vision of seeding biomedical innovation for the benefit of patients”, Christian Tidona, Founder and Managing Director of the BioMed X Institute, highlights. “Merck, Darmstadt, Germany, was our first industry partner when BioMed X was launched in 2013, and we are delighted to strengthen our collaboration with them through this new exciting project.” Further details about this new research project can be found on the website of the BioMed X Institute at www.bio.mx.
phone +49 6221 426 11 0
email info@bio.mx
web bio.mx/
email BioMed X GmbH Im Neuenheimer Feld 515 69120 Heidelberg
 
Print this page
Send to a friend
   
spacer
News and Press Releases

Datwyler to Double Capacity at its Indian Facility

Datwyler is increasing capacity for all three of its production standards in Pune, India. The expansion will nearly double capacity and add 400 jobs.
More info >>


White Papers

Backward Thinking: The Reverse Engineering of A Pressurized Metered Dose Inhaler

Development of a generic equivalent to a current marketed pressurized metered dose inhaler (pMDI) product brings immense challenges. Thorough analysis is critical to gain a comprehensive understanding of the physical attributes and pharmaceutical performance of the reference marketed product. Many factors need to be assessed, understood and combined in order to successfully develop a generic pMDI which will meet the regulatory and quality requirements as an equivalent product in the anticipated target market. Significant information about the reference marketed product can be obtained from a thorough review of published literature, specifically the Summary of Product Characteristics (SPC) and Patient Information Leaflet (PIL). Additionally, baselining the reference marketed product for pharmaceutical performance offers a working target specification for in-vitro correlation. It will ensure the smoothest possible path to commercialization and maximize return on investment. In addition, baselining of the reference marketed product is done to understand batch-to-batch variability and product performance over the stated shelf life to establish targets for critical quality attributes (CQAs), which can be applied to the generic equivalent pMDI.
More info >>

 
©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement