|
|
|
| home > white papers > Medpace Reference Laboratories establishes state of the art Flow Cytometry techniques for flexible approaches to clinical trials across multiple therapeutic areas. - Medpace |
|
|
 WHITE PAPERS |
|
Medpace
|
|
Medpace Reference Laboratories establishes state of the art Flow Cytometry techniques for flexible approaches to clinical trials across multiple therapeutic areas.
|
|
Cytometry is the process of measuring the properties of individual cells. These properties may include gene or protein expression, chemical properties, deoxyribonucleic acid (DNA) content, and various cellular functions. The earliest methods of cytometry relied upon light microscopy for the classification and observation of cells and cellular components. Microscopy permitted direct visual observation of cells for the first time, leading to the classification of cells by morphology and insight into cellular functions. However, the time required for microscopic analysis constrains the number of samples or number of cells in each sample that can be examined. Therefore, the utility of microscopy for analysis of rare cells or in situations where sample throughput is a priority is limited. Flow cytometry was developed largely to improve upon these limitations.
Flow cytometry depends upon the ability to pass cells single file in a solution through the path of one or more laser beams. Flowing cells through the path of the laser permits the analysis of thousands of cells per second, but requires that the cells in the sample are in a single-cell, liquid suspension. Therefore, solid tissue samples require dissociation through mechanical or enzymatic processing before analysis. A wide variety of information about the cell can be determined depending upon how the cell interacts with the light from the laser. Detectors that measure the manner in which the cell scatters light can provide information about the size of the cell as well as complexity due to presence of intracellular granules and irregularities in the shape of the cell membrane. On the basis of light scatter properties alone, three distinct populations of leukocytes can be resolved in the peripheral blood: lymphocytes, monocytes and granulocytes. However, the power and flexibility of flow cytometry is fully realized when fluorescent probes that can be excited by the light from the laser are incorporated.
|
|
|
|
|
|
|
 |
News and Press Releases |
 |
Hope for a new treatment for the autoimmune neuromuscular disease Myasthenia Gravis (MG)
- The biotech companies 3P Biopharmaceuticals and Toleranzia collaborate for that MG treatment
- MG is an orphan disease which has a major unmet medical need and a large market potential
- The drug candidate,TOL2, has already achieved several positive preclinical results
More info >> |
|
 |
White Papers |
 |
|
The Promise and Challenge of Adaptive Design in Oncology Trials
Medpace
Clinical oncology trials are more complex and time consuming than those
in any other therapeutic area and failure rates are frustratingly high.
Given the urgent need for new oncologic therapies, sponsors are eager to
find more effective ways to conduct clinical research.
Incorporating adaptive design methodologies into clinical trials can
reduce costs and enhance efficiency while maintaining trial integrity.
They can also reduce the number of patients on placebo and
sub-therapeutic doses. In light of this promise, regulatory bodies have
created guidelines supportive of adaptive design.
More info >> |
|
 |
Industry Events |
 |
12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
8-11 February 2021, Vienna, Austria
In continuation of the very successful scientific meetings in Budapest, Paris, Berlin, Florence, Geneva, Barcelona, Malta, Istanbul, Lisbon, Glasgow and Granada, the 12th PBP World will be held in Vienna from 8-11 Feb 2021. This every two year held conference has gained an ever increasing impact among the pharmaceutical scientists: With up to 1000 submitted abstracts and about 1300 participants it has become a well-established major meeting, attracting scientists from all over the world.
More info >> |
|
|
|
.jpg)
