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Iksuda to present IKS014 Phase 1 data at ESMO

October 14, 2025 – Clinical Trials, Drug Discovery, Other, Pharmaceutical – ESMO 2025, HER2+ solid tumours, Iksuda, antibody drug conjugates, clinical trials, oncology

14 October 2025 — Newcastle, UK — Iksuda Therapeutics (Iksuda), the developer of class-leading antibody drug conjugates (ADCs), will present new data from its Phase 1 study of IKS014, a human epidermal growth factor receptor 2 (HER2) ADC, in patients with advanced HER2+ solid tumours, at the European Society for Medical Oncology (ESMO) Congress in Berlin, Germany (17-21 October).

Poster Presentation details:

Abstract Title:	A Phase 1 Dose Escalation Trial of IKS014, a HER2-Targeting Antibody Drug Conjugate (ADC), in Participants with Advanced HER2+ Solid Tumors
Session Title:	Developmental Therapeutics
Date/Time:	19 October 2025/12:00-12:45 CET
Location:	Level 2, Hall 25
Poster Number:	936P

The Phase 1 study (NCT05872295) is a non-randomised, open-label, multicentre trial evaluating IKS014 in patients with locally advanced or metastatic solid tumours that express HER2. Data will be presented from the dose escalation portion of the trial conducted in Australia, which was designed to establish the Maximum-tolerated dose and/or Recommended Phase 2 Dose for IKS014 as monotherapy and to provide initial safety, tolerability, efficacy, PK, PD, and immunogenicity characteristics of the ADC.

About Iksuda Therapeutics
Iksuda Therapeutics is a clinical stage, UK-based biotechnology company focussed on the development of class leading antibody drug conjugates (ADCs) targeting difficult-to-treat haematological and solid tumours. Iksuda’s pipeline of ADCs is centred on a portfolio of prodrug DNA and protein alkylating payloads in combination with stable conjugation chemistries including its proprietary PermaLink platform. The Company’s design concepts for ADCs are now clinically validated to significantly improve the therapeutic index of this important modality and improve the outcomes for patients living with cancer. Visit: www.iksuda.com.